These days, hangover can also suggest an emotional letdown or an undesirable prolongation of notes or sounds from a loudspeaker. Examples of hangover in a Sentence She woke up with a hangover. Send us feedback. Sign Up Dictionary Entries near hangover hangout hang out hang out one's shingle hangover hangrod hangry hangtag. Accessed 24 Sep. Keep scrolling for more More Definitions for hangover hangover. Please tell us where you read or heard it including the quote, if possible.
Consequences of the alcohol induced redox changes in the human body include increased triglyceride production, increased amino acid catabolism , inhibition of the citric acid cycle , lactic acidosis , ketoacidosis , hyperuricemia , disturbance in cortisol and androgen metabolism and increased fibrogenesis. The metabolism of glucose and insulin are also influenced. Alcohol also induces the CYP2E1 enzyme, which metabolizes ethanol and other substances into more reactive toxins.
In particular, in binge drinking the enzyme is activated and plays a role in creating a harmful condition known as oxidative stress which can lead to cell death. Acetaldehyde, the first by-product of ethanol, is between 10 and 30 times more toxic than alcohol itself  and can remain at an elevated plateau for many hours after initial ethanol consumption.
For example, some people predominantly East Asians have a mutation in their alcohol dehydrogenase gene that makes this enzyme unusually fast at converting ethanol to acetaldehyde. In addition, about half of all East Asians convert acetaldehyde to acetic acid more slowly via acetaldehyde dehydrogenase , causing a higher buildup of acetaldehyde than normally seen in other groups.
Since the alcohol flush reaction is highly uncomfortable and the possibility of hangovers is immediate and severe, people with this gene variant are less likely to become alcoholics. Acetaldehyde may also influence glutathione peroxidase , a key antioxidant enzyme, and increases the susceptibility to oxidative stress.
One study found that injecting sodium acetate into rats caused them to have nociceptive behavior headaches. In addition, there is a biochemical explanation for this finding. High acetate levels cause adenosine to accumulate in many parts of the brain. But when the rats were given caffeine, which blocks the action of adenosine, they no longer experienced headaches. In addition to ethanol and water, most alcoholic drinks also contain congeners , either as flavoring or as a by-product of fermentation and the wine aging process.
While ethanol is by itself sufficient to produce most hangover effects, congeners may potentially aggravate hangover and other residual effects to some extent. Congeners include substances such as amines , amides , acetones , acetaldehydes, polyphenols , methanol, histamines , fusel oil , esters , furfural , and tannins , many but not all of which are toxic.
In general, dark liquors have a higher concentration while clear liquors have a lower concentration. Whereas vodka has virtually no more congeners than pure ethanol, bourbon has a total congener content 37 times higher than that found in vodka. Several studies have examined whether certain types of alcohol cause worse hangovers.
One even showed that hangovers were worse and more frequent with darker liquors. One potent congener is methanol. It is naturally formed in small quantities during fermentation and it can be accidentally concentrated by improper distillation techniques. Find out if you have the knowledge to survive this prickly foray into the desert! This tall, horizontally branched cactus is probably the most recognizable cactus in Arizona. What is it called? Origin of hangover —95, Americanism ; noun use of verb phrase hang over.
He finds almost anything a fat man does to be hilarious. When he finds his clothes and his henchmen, he is not to be trifled with. Jade Heather Graham , a stripper, is forthright: "Well, actually, I'm an escort, but stripping is a good way to meet clients. The search for Doug has the friends piecing together clues from the ER doctor, Mike Tyson's security tapes and a mattress that is impaled on the uplifted arm of one of the Caesars Palace statues. The plot hurtles through them. If the movie ends somewhat conventionally, well, it almost has to; narrative housecleaning requires it.
It begins conventionally, too, with uplifting music and a typeface for the titles that may remind you of " My Best Friend's Wedding. Here is a movie that deserves every letter of its R rating. What happens in Vegas stays in Vegas, especially after you throw up. Roger Ebert was the film critic of the Chicago Sun-Times from until his death in The easiest way is to drink orange juice for a healthy dose of Vitamin C.
If you have a multivitamin in the house, now is also a good time to take that as well. Food may seem like the last thing you want right now, but it can help and it doesn't have to be much or anything that will make you sick.
Eat mineral- and protein-rich food, even if you don't feel like it. Begin with something bland, like a piece of bread, a few crackers or pretzels, or a banana. Your mother gave you chicken noodle soup when you were sick as a kid, right?
Try that now. It is packed with protein and minerals and you can always just slurp the soothing broth. If you're up for it, take a few minutes to whip up a hangover-friendly breakfast. Some people swear by fast food when they're hungover. You may want to drag yourself down the street for a greasy burger and fries if you can stomach the thought.
When even standing seems like a challenge, it takes willpower to get up and move. However, there is some truth to the benefits of a little exercise.
It is not a magic cure, but it can help restore your body and mind. It can also increase your metabolism, ridding your body of the toxins a little faster. There's no need to work up a sweat, either. A short walk in the fresh air can really do wonders.
If your hangover is at the level where even that is not a good idea, take a few minutes to just sit outside and breathe. A little sunshine and a light breeze have wonderful restorative powers. Your head is pounding and it's tempting to reach for a quick pain reliever. This is not the best idea when you're dealing with a hangover. Two songs for the A side owned the swiss mates with a fast, noisy street punk and other three songs for the B side, where the italian punx stallions put some pogo punk influenced by the japanese sound.
I like the graphics, rude but funny for sure and the attitude that move the whole EP, and i think the two bands are well mixed together, also if they play a very different kind of sound. These guys aren't technical champions and they neither want to do that, what you will own will be just an healty bunch of punx music, for some sides enjoyable also by the oi!Jun 19, · 1. I was left in no doubt about the severity of the hangover when a cat stamped into the room. Mr Mulliner Speaking by PG Wodehouse () 2. Her head felt like elephants were doing the merengue on her cerebellum. Move the Sun by Susan Fanetti () 3. Champagne and Benzedrine! Never again! Casino Royale by Ian Fleming () 4.